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Slideshow

Publications

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

  • Moreno, S.N.J., Ayong, L., and Pace, D. A. (2011) Calcium storage and function in apicomplexan parasites. Essays Biochem. 51, 97-110.
  • Pace, D.A., Fang, J., Cintrón, R., Docampo, M. D., and Moreno, S. N. J. (2011) Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of pyrophosphate in glycolysis for Toxoplasma gondii. Biochem. J. 440, 229-240.
  • Docampo, R., Jimenez, V., King-Keller, S., and Moreno, S. N. J. (2011) The role of acidocalcisomes in the stress response of Trypanosoma cruzi. Adv. Parasitol. 75, 307-324.
  • Docampo, R., and Moreno, S. N. J. (2011) Acidocalcisomes. Cell Calcium 50, 113-119
  • Nair, S. C., Brooks, C. F., Goodman, C. D., Strurm, A., McFadden, G. I., Sundriyal, S., Anglin, J. L., Song, Y., Moreno, S. N. J., and Striepen, B. (2011) Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J. Exp. Med. 208, 1547-59.
  • Francia, M.E., Wicher, S., Pace, D.A., Sullivan, J., Moreno, S.N.J., and Arrizabalaga, G. (2011) A Toxoplasma gondii protein with homology to intracellular type Na+/H+ exchangers is important for osmoregulation and invasion. Exp. Cell Res. 317, 1382-1396.
  • Rohloff, P., Miranda, K., Rodrigues, J.C.F., Fang, J., Galizzi, M., Plattner, H., Hentschel, J., and Moreno, S.N.J. (20110 Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii. PLoS One 6, e18390.
  • Rooney, P.J., Ayong, L., Tobin, C.M., Moreno, S.N.J., and Knoll, L.J. (2011) TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii. Mol. Biochem. Parasitol. 176, 121-126.
  • Rosso, V.S., Szajnman, S.H., Malayil, L., Galizzi, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2011) Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem. 19, 2211-2217.

2010

  • Martins V.P., Okura M., Maric D., Engman D.M., Vieira M., Docampo R., Moreno S.N. (2010) Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J. Biol Chem., 285 (40) 30906-30917.
  • Martins, V.P., Galizzi, M., Docampo, R., and Moreno, S.N.J. (2010) Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis. Inf. Immun., 78 (10) 4206-4212.
  • Miranda, K., Pace, D.A., Cintron, R., Rodrigues, J.C.F., Fang, J., Smith, A., Rohloff, P., Coelho, E., de Haas, F., de Souza, W., Coppens, I., Sibley, L.D., and Moreno, S.N.J. (2010) Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol. Microbiol. 7(6) 1358-1375.
  • Docampo, R., and Moreno, S.N.J. (2010) Biochemistry of Trypanosoma cruzi. In “American Trypanosomiasis” (Tybairenc, M. and Telleria, J., Eds), Elsevier, pp. 365-392.
  • Docampo, R., Ulrich, P., and Moreno, S.N.J. (2010) Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Phil. Trans. R. Soc. B365, 775-784.

2009

  • Moreno, S.N.J., and Docampo, R. (2009) The role of acidocalcisomes in parasitic protists. J. Eukaryot. Microbiol. 56, 208-213.

2008

  • Moreno S.N.J., Li Z.H. (2008). Targeting the isoprenoid pathway of Toxoplasma gondii. Expert Opin Ther Targets. 2008 Mar;12(3):253-63.
  • Miranda, K. de Souza, W. Plattner, H. Hentschel, J. Kawazoe, U. and Moreno, SNJ. (2008) Acidocalcisomes in Apicomplexan parasites . Exp. Parasitol.,118:2-9.
  • Docampo, R., and Moreno, S.N. (2008) The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites. Curr. Pharm. Design,14, 882-888.
  • Szajnman, S.H., García Liñares, G.G., Li, Z-H., Jang, C., Galizzi, M., Bontempi, E., Ferella, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2008) Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem.,16, 3283-3290.
  • Nagamune, K., Moreno, S.N., Chini, E.N., Sibley, L.D. (2008) Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem. 47, 70-81.

2007

  • Nagamune K, Beatty WL, Moreno SN, Sibley, LD. Artemisinin induces calcium-dependent secretion in Toxoplasma gondii (2007) Antimicrob. Agents Chemother. 51(11):3816-23.
  • Ling Y, Li ZH, Miranda K, Oldfield E, Moreno SN. The farnesyl diphosphate/geranylgeranyl diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and the molecular target of bisphosphonates (2007) J. Biol. Chem. 282(42):30804-16.
  • Linares GG, Gismondi S, Codesido NO, Moreno SN, Docampo R, Rodriguez JB. Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5068-5071.
  • Moreno SN. Drugs Against Protozoan Parasites - a Keystone Symposium. IDrugs. 2007 10(4):240-2.
  • Moreno, S.N.J., Miranda, K., Fang, J., Rohloff, P. and de Souza. W. (2007) Calcium storage and homeostasis in Toxoplasma gondii. In: “Toxoplasma gondii: The Model Apicomplexan---Perspective and Methods”. Editors: Louis M. Weiss and Kami Kim. Elsevier-Academic Press. Chapter 10.
  • Nagamune, K., Moreno, S.N.J., Chini, E. N. and Sibley, L. D. (2007). Calcium regulation and signaling in apicomplexan parasites In: “Molecular Mechanisms of Parasite Invasion”. Editors: Barbara Burleigh and Dominique Soldati. In press.
  • Moreno, S.N.J., Miranda, K. and De Souza, W. (2007). Calcium homeostasis and acidocalcisomes in Toxoplasma gondii. In:The biology of Toxoplasma gondii. Eds: James Ajioka and Dominique Soldati. Horizon Scientific press. Chapter 26. 

2006

  • Fang J, Marchesini N, Moreno SN. (2006) A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol. Biochem J.394:417.
  • Harper JM, Huynh MH, Coppens I, Parussini F, Moreno SN, Carruters VB. A Cleavable Propeptide Influences Toxoplasma Infection by Facilitating the Trafficking and Secretion of the TgMIC2-M2AP Invasion Complex. (2006) Mol. Biol. Cell. 17(10):4551-63.

2005

  • Luo, S., Ruiz, F.A., and Moreno, S.N.J. (2005) The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence. Mol. Microbiol. 55:1034-1045.
  • Marshesini N, Vieira, M. Moreno, S.N.J., Docampo, R. A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte (2005). J. Biol. Chem.  280: 36841-7.
  • Docampo, R., de Souza, W., Miranda, K., Rohloff, R., and Moreno, S.N.J. (2005) Acidocalcisomes –conserved from bacteria to man. Nat. Rev. Microbiol. 3:251-261.
  • Okura M, Fang J, Salto ML, Singer RS, Docampo R, Moreno S.N.J. (2005) A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J. Biol. Chem. 280:16235-43.
  • Ling, Y., Sahota, G., Odeh, S., Chan, J.M., Araujo, F., Moreno, S.N.J. and Oldfield, E. (2005) Bisphosphonate inhibitors of Toxoplasma gondii growth: in vitro, QSAR and in vivo investigations. J. Med. Chem. 48:3130-3140.