Publications

2024

• Hortua Triana, M. A., Marquez-Nogueras, K. M., Fazli, M. S., Quinn, S. & Moreno, S. N. J. Regulation of calcium entry by cyclic GMP signaling in Toxoplasma gondii. J. Biol. Chem. 300, 105771 (2024). 

2022

• Sleda, M.A., Li, Z.H., Behera, R., Baierna, B., Li, C., Jumpathong, J., Malwal, S.R., Kawamukai, M., Oldfield, E. Moreno, S.N.J. (2022). The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against Toxoplasma gondii infection. mBio, 13 (5): e0196622. doi: 10.1128/mbio.01966-22
• Herneisen, A.L., Li, Z.H., Chan, A.W., Moreno, S.N.J., Lourido, S. (2022) De novo mapping of the apicomplexan Ca²⁺-responsive proteome. Elife 11: e80336. doi: 10.7554/eLife.80336.
• Stasic, A.J., Carruthers, V., Moreno, S.N.J. and Dou, Z. (2022). The Plant-like Vacuolar Compartment (PLVAC) of Toxoplasma gondii. Special issue on organelles of protists. J. Euk. Microbiol. e12951. doi: 10.1111/jeu.12951
• Baek, K.H., Phan, T.N., Malwal, S.R., Lee, H.  Li, Z.H., Moreno, S.N.J. Oldfield, E. and No, J.H. (2022). In vivo efficacy of SQ109 against Leishmania donovani, Trypanosoma spp. and Toxoplasma gondii. Biomedicines. 10(3):670. doi: 10.3390/biomedicines10030670.

2021

• Fu Y, Brown KM, Jones, NG, Moreno, S.N.J., Sibley, LD. (2021) Reduced calcium storage blunts calcium signaling in Toxoplasma bradyzoites and impedes motility and egress Elife. Dec 3;10:e73011. doi: 10.7554/eLife.73011
• Docampo, R., Moreno, S.N.J. (2021) Calcium signaling in intracellular protist parasites. Curr. Opin. Microbiol. 64:33-40. doi: 10.1016/j.mib.2021.09.002.
• Stasic, A.J., Dykes, E.J., Cordeiro, C.D., Vella, S.A., Fazli, M.S., Quinn, S., Docampo, R. Moreno, S.N.J. (2021). Ca²⁺ entry at the plasma membrane and uptake by acidic stores is regulated by proton transport in Toxoplasma gondii. Mol. Microbiol. 115(5):1054-1068
• Márquez-Nogueras, K.M., Chasen, N. M.  Hortua Triana, M.A., Kuo, I. Y.  Moreno, S.N.J.  (2021). Calcium signaling through a Transient Receptor Channel is important for Toxoplasma gondii growth. Elife, 10:e63417. doi: 10.7554/eLife.63417.
• Li, Z.H., King, T., Ayong, L. Vella, S. Chasen, N., Patel, S. Moreno, S.N.J. (2021). A plastid Two-Pore Channel that is relevant for organelle integrity and whole cell fitness. Nat. Commun. 12(1):5802. doi: 10.1038/s41467-021-25987-5.
• Vella, S.A., Moore, C.A., Li, Z., Hortua Triana, M.A., Potapenko, E. Moreno, S.N.J. (2021). The Role of Potassium and Host Calcium Signaling in Toxoplasma gondii Egress. Cell Calcium, 94:102337

2020

• McPhillie, M.J. et al , Biagini, G. A., Moreno, S.N., Roberts C.W., Antonyuk, S.V., Fishwick, C.W.G., McLeod, R.(2021) Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Front Cell Infect Microbiol. 2020 9;10:203. doi: 10.3389/fcimb.2020.00203.
• Wendimu, M., Alqinyah M., Vella, S.A., Almutairi, F., Freeman, P., Rayatpisheh, S., Wohlschlegel, J., Moreno, S.N., and Hooks, S.B. (2020). STIM2 interaction with Regulator of G protein Signaling 10 (RGS10) reveals a critical role for store operated calcium entry in RGS10 regulation of COX-2 expression. Cell Signal.  2021 Mar 9;83:109974. doi: 10.1016/j.cellsig.2021.109974. 
• Fierro, M.A., Brooks, C.F., Asady, B., Moreno, S.N.J. and Muralidharan, V. (2020) An ER-resident calcium binding protein modulates egress of malaria parasites from erythrocytes. mBio, 11 (1): e03078-19.
• Vella, S., Calixto, A., Asady, B., Li, Z. Moreno, S. N. J. (2020). Genetic Indicators for Calcium Signaling studies in Toxoplasma gondii. Meth. Mol. Biol., Invited chapter, 2071:187-207
• Huang, G., Moreno, S.N.J., Docampo, R. (2020). Isolation and characterization of acidocalcisomes of trypanosomatids. Meth. Mol. Biol., 2116:673-688. doi: 10.1007/978-1-0716-0294-2_40. PMID: 32221949

2019

• Pace, D.A, Moreno^, S.N.J., Lourido, S. (2019) In: “Toxoplasma gondii: The Model Apicomplexan---Perspective and Methods”. Editors: Louis M. Weiss and Kami Kim. Elsevier-Academic Press. Chapter 10. Third Edition.
• Chasen, N., Stasic, A. J., Asady, B., Coppens, I. and Moreno, S. N. J. The Vacuolar Zinc Transporter TgZnT Protects Toxoplasma gondii from Zinc Toxicity. (2019), mSphere, 4(3): e00086-19.
• Thornton, L.B., Teehan, P., Floyd, K., Cochrane, C., Bergman, A., Riegel, B., Stasic, A.J., Cristina, M.D., Moreno, S.N.J., Roepe, P.D., Dou, Z.  (2019). An ortholog of P. falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion. Plos Pathogens, 15(6):e1007775
• Stasic, A.J., Chasen, N., Dykes, E.J., Asady, B., Vella, S.A., Starai, V.J., and Moreno, S.N.J. (2019) The Toxoplasma Vacuolar H⁺-ATPase regulates intracellular pH and controls the maturation of essential secretory proteins. Cell Reports, 27(7):2132-2146

2018

• Hortua Triana, A.M., Marquez-Nogueras, K, Vella, S., Moreno, S.N.J. (2018). Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii. BBA-Molecular Cell Research. 865: 1846-1856
• Chang, Le, Dykes, E., Li, J., Moreno, S.N.J., Hortua Triana, M.A. (2018). Characterization of Two EF-hand Domain-containing Proteins from Toxoplasma gondii. J. Euk Microbiol. 66, 343–353
• Cruz-Bustos T, Moreno S.N.J., Docampo R. (2018). Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes. J. Euk. Microbiol. 65, 722–728
• Hortua Triana, A.M., Marquez-Nogueras, K., Chang, L., Stasic, A.J., Spiegel K.A., Sharma A., Li, Z., Moreno, S.N.J. (2018). High-Performance probes for the detection of weakly expressed Toxoplasma gondii calcium-related genes. J. Euk. Microbiol. 65, 709–721
• Fazli, M.S., Vella, S.A. Moreno, S.N.J. and Quinn, S. (2018) Unsupervised discovery of Toxoplasma gondii motility phenotypes. The Engineering in Medicine and Biology Conference Management System.

2017

• Li, Z.-H., Li, C., Szajnman, S.H., Rodriguez, J.J., Moreno, S.N.J. (2017) Synergistic activity between statins and bisphosphonates against acute experimental toxoplasmosis. Antimicrob. Agents Chemother. 61: e02628-16.
• Chasen, N., Assady, B., Lembgruber, L., Vommaro, R.C., Kissinger, J., Coppens, I., Moreno, S.N.J. (2017) A glycosylphosphatidylinositol-anchored carbonic anhydrase-related prpotein of Toxoplasma gondii is important for rhoptry biogenesis and virulence. mSphere 2: e00027
• LaFavers, K.A., Márquez-Nogueras, K.M., Coppens, I., Moreno, S.N.J., Arrizabalaga, G. (2017) A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii. Cell. Microbiol. 19: e12749.
• Galaka, T, Ferrer Casal, M., Storey, M., Li, C., Cahoa,M.N., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez,J.B. (2017) Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and Apicomplexan parasites. Molecules 22, 82
• Chao, M.N., Storey, M., Li, C., Rodriguez, M.C., Si Salvo, F., Szajnman, S.H., Moreno, S.J., Docampo, R., Rodriguez, J.B. (2017) Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation. Bioorg. Med. Chem. 25, 6435-6449.
• Szajnman, S., Galaka, T., Li, Z.-H., Li, C., Howell, N.M., Chao, M.N., Striepen, B., Muralidharan, V., Moreno, S.N.J., Rodriguez, J.B. (2017) In vitro and in vivo ctivities of sulfur-containing linear bisphosphonates against Apicomplexan parasites. Antimicrob. Agents Chemother. 61: e01590-16.
• Docampo, R., and Moreno, S.N.J. (2017) Biochemistry of Trypanosoma cruzi. In American Trypanosomiasis, 2nd Ed. (Tybairenc, M. and Telleria, J., Eds), Elsevier.

2016

• Moreno, S.N.J. (2016) Keep up the good (bench) work. Trends Parasitol. 32, 579-580.
• Sidik, S.M., Hortua-Triana, M.A., Paul, A.S., El Bakkouri, M., Hackett, C.G., Tran, F., Westwood, N.J., Hui, R., Zuercher, W.J., Duraisingh, M.T., Moreno, S.N.J., Lourido, S. (2016) Using a genetically encoded sensor to identify inhibitors of Toxoplasma gondii Ca2+ signaling. J. Biol. Chem. 291, 9566-9580.
• Chao, M.N., Li, C., Storey, M., Falcone, B.N., Szajnman, S.H., Bonesi, S.M., Docampo, R., Moreno, S.N., and Rodriguez, J.B. (2016) Activity of fluorine-containing analogues of WC-9 and structurally related analogues against two intracellular parasites: Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem 11. 2690-2702.

2015

• Borges, L., Budu, A., McKnight, C, Moore, C., Vella, S., Hortua Triana, M.A., Liu, J., Garcia, C., Pace, D. A., Moreno, S.N.J. (2015) Calcium signaling throughout the Toxoplasma gondii lytic cycle. A study using genetically encoded calcium indicators. J. Biol. Chem. 290, 26914-26926.
• Lourido, S., and Moreno, S.N.J. (2015) The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. Cell Calcium 57, 1861-93.
• King-Keller, S., Moore, C.A., Docampo, R., and Moreno, S.N.J. (2015) Ca2+ regulation of Trypanosoma brucei phosphoinositide phospholipase C. Eukaryot. Cell, 14(5), 486-494.
• Chao, M.N., Matiuzzi, C.E., Storey, M., Li, C., Szajnman, S.H., Docampo, R., Moreno, S.N., and Rodriguez, J.B. (2015) Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem. 10, 1094–1108

2014

• Pace, D.A., Mcknight, C.A., Liu, J., Jimenez, V., and Moreno, S.N.J. (2014) Calcium entry in Toxoplasma gondii and its enhancing effect of invasion-linked traits. J. Biol. Chem. 289, 19637-19647.
• Liu, J., Pace, D., Dou, Z., King, T. P., Guidot, D., Carruthers, V. B., and Moreno, S.N.J. (2014) A vacuolar H+-pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of Toxoplasma gondii. Mol. Microbiol. 93, 698-712.
• Moreno, S.N.J., Borges Pereira, L, and Pace, D. (2014) Calcium storage and homeostasis in Toxoplasma gondii. In Toxoplasma gondii, The Model Apicomplexan, Perspectives and Methods, 2nd edition. Weiss, L, and Kim, K, Eds.  Elsevier Ltd., Amsterdam, pp. 351-374.
• Ferrer-Casal, M, Li, C., Galizzi, M., Storz, C.A., Szajnman, S., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2014) New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorg. Med. Chem. 22, 398-405.
• Docampo, R., Moreno, S.N.J., and Plattner, H. (2014) Intracellular calcium channels in protozoa. Eur. J. Pharmacol. 739, 4-18.
• Tang, Q., Andenmatten, N., Hortua-Triana, M.A., Deng, B., Meissner, M., Moreno, S.N.J., Ballif, B.A., and Ward, G.E. (2014) Calcium-dependent phosphorylation alters Class XIVa myosin function in the protozoan parasite Toxoplasma gondii. Mol. Biol. Cell. 25, 2579-2591. 
• Huang, G., Ulrich, P.N., Storey, M., Johnson, D., Tischer, J., Tovar, J.A., Moreno, S.N., Orlando, R. and Docampo, R. (2014) Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells. PLoS Path. 10 (12): e1004555.
• Docampo, R., and Moreno, S.N.J. (2014) Calcium in malaria parasites. In M. Hommel & P.G. Kremsner (Eds) Encyclopedia of Malaria, Springer, in press

2013

• Li, Z.H., Ramakrishnan, S., Striepen, B., and Moreno, S.N.J. (2013) Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin. PLoS Pathog. 9, e1003665.
• Recher, M., Barboza, A.P., Li, Z.-H., Galizzi, M., Ferrer-Casal, M., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2013) Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur. J. Med. Chem. 60, 431-440.
• Huang, G., Bartlett, P.J., Thomas, A.P., Moreno, S.N.J., and Docampo, R. (2013) Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Proc. Natl. Acad. Sci. U.S.A.110, 1887-1892.
• Moreno, S.N.J., and Docampo, R. (2013) Polyphosphate and its diverse functions in host cells and pathogens. PLoS Pathog. 9(5):e1003230
• Cai, G., Deng, L., Xue, J., Moreno, S.N.J., Striepen, B., and Song, Y. (2013) Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-d-xylulose-5-phosphate reductoisomerase. Bioorg. Med. Chem. Lett.23(7):2158-61.
• De Napoli, M.G., de Miguel, N., Lebrun, M., Moreno, S.N.J., Angel, S.O., and Corvi, M.M. (2013) N-terminal palmitoylation is required from Toxoplasma gondii HSP20 inner membrane localization. Biochim. Biophys. Acta (Mol. Cell Res)1833(6):1329-37.
• Elicio, P., Chao, M.N., Galizzi, M., Li, C., Szajnman, S.H., Docampo, R., Moreno, S.N.J., and Rodriguez, J.B. (2013) Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. Eur. J. Med. Chem. 69C, 480-489.

2012

• Li ZH, Cintrón R, Koon NA, Moreno SNJ (2012) The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase. Biochemistry 51, 7533-7540.
• Szajnman, S., Rosso, V., Malayil, L., Smith, A., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2012) 1-(fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Org. Biomol. Chem.  10, 1424-1433.

2011

• Moreno, S.N.J., Ayong, L., and Pace, D. A. (2011) Calcium storage and function in apicomplexan parasites. Essays Biochem. 51, 97-110.
• Pace, D.A., Fang, J., Cintrón, R., Docampo, M. D., and Moreno, S. N. J. (2011) Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of pyrophosphate in glycolysis for Toxoplasma gondii. Biochem. J. 440, 229-240.
• Docampo, R., Jimenez, V., King-Keller, S., and Moreno, S. N. J. (2011) The role of acidocalcisomes in the stress response of Trypanosoma cruzi. Adv. Parasitol. 75, 307-324.
• Docampo, R., and Moreno, S. N. J. (2011) Acidocalcisomes. Cell Calcium 50, 113-119
• Nair, S. C., Brooks, C. F., Goodman, C. D., Strurm, A., McFadden, G. I., Sundriyal, S., Anglin, J. L., Song, Y., Moreno, S. N. J., and Striepen, B. (2011) Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J. Exp. Med. 208, 1547-59.
• Francia, M.E., Wicher, S., Pace, D.A., Sullivan, J., Moreno, S.N.J., and Arrizabalaga, G. (2011) A Toxoplasma gondii protein with homology to intracellular type Na+/H+ exchangers is important for osmoregulation and invasion. Exp. Cell Res. 317, 1382-1396.
• Rohloff, P., Miranda, K., Rodrigues, J.C.F., Fang, J., Galizzi, M., Plattner, H., Hentschel, J., and Moreno, S.N.J. (20110 Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii. PLoS One 6, e18390.
• Rooney, P.J., Ayong, L., Tobin, C.M., Moreno, S.N.J., and Knoll, L.J. (2011) TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii. Mol. Biochem. Parasitol. 176, 121-126.
• Rosso, V.S., Szajnman, S.H., Malayil, L., Galizzi, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2011) Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem. 19, 2211-2217.

2010

• Martins V.P., Okura M., Maric D., Engman D.M., Vieira M., Docampo R., Moreno S.N. (2010) Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J. Biol Chem., 285 (40) 30906-30917.
• Martins, V.P., Galizzi, M., Docampo, R., and Moreno, S.N.J. (2010) Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis. Inf. Immun., 78 (10) 4206-4212.
• Miranda, K., Pace, D.A., Cintron, R., Rodrigues, J.C.F., Fang, J., Smith, A., Rohloff, P., Coelho, E., de Haas, F., de Souza, W., Coppens, I., Sibley, L.D., and Moreno, S.N.J. (2010) Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol. Microbiol. 7(6) 1358-1375.
• Docampo, R., and Moreno, S.N.J. (2010) Biochemistry of Trypanosoma cruzi. In “American Trypanosomiasis” (Tybairenc, M. and Telleria, J., Eds), Elsevier, pp. 365-392.
• Docampo, R., Ulrich, P., and Moreno, S.N.J. (2010) Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Phil. Trans. R. Soc. B365, 775-784.

2009

• Moreno, S.N.J., and Docampo, R. (2009) The role of acidocalcisomes in parasitic protists. J. Eukaryot. Microbiol. 56, 208-213.

2008

• Moreno S.N.J., Li Z.H. (2008). Targeting the isoprenoid pathway of Toxoplasma gondii. Expert Opin Ther Targets. 2008 Mar;12(3):253-63.
• Miranda, K. de Souza, W. Plattner, H. Hentschel, J. Kawazoe, U. and Moreno, SNJ. (2008) Acidocalcisomes in Apicomplexan parasites . Exp. Parasitol.,118:2-9.
• Docampo, R., and Moreno, S.N. (2008) The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites. Curr. Pharm. Design,14, 882-888.
• Szajnman, S.H., García Liñares, G.G., Li, Z-H., Jang, C., Galizzi, M., Bontempi, E., Ferella, M., Moreno, S.N.J., Docampo, R., and Rodriguez, J.B. (2008) Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg. Med. Chem.,16, 3283-3290.
• Nagamune, K., Moreno, S.N., Chini, E.N., Sibley, L.D. (2008) Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem. 47, 70-81.

2007

• Nagamune K, Beatty WL, Moreno SN, Sibley, LD. Artemisinin induces calcium-dependent secretion in Toxoplasma gondii (2007) Antimicrob. Agents Chemother. 51(11):3816-23.
• Ling Y, Li ZH, Miranda K, Oldfield E, Moreno SN. The farnesyl diphosphate/geranylgeranyl diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and the molecular target of bisphosphonates (2007) J. Biol. Chem. 282(42):30804-16.
• Linares GG, Gismondi S, Codesido NO, Moreno SN, Docampo R, Rodriguez JB. Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5068-5071.
• Moreno SN. Drugs Against Protozoan Parasites - a Keystone Symposium. IDrugs. 2007 10(4):240-2.
• Moreno, S.N.J., Miranda, K., Fang, J., Rohloff, P. and de Souza. W. (2007) Calcium storage and homeostasis in Toxoplasma gondii. In: “Toxoplasma gondii: The Model Apicomplexan---Perspective and Methods”. Editors: Louis M. Weiss and Kami Kim. Elsevier-Academic Press. Chapter 10.
• Nagamune, K., Moreno, S.N.J., Chini, E. N. and Sibley, L. D. (2007). Calcium regulation and signaling in apicomplexan parasites In: “Molecular Mechanisms of Parasite Invasion”. Editors: Barbara Burleigh and Dominique Soldati. In press.
• Moreno, S.N.J., Miranda, K. and De Souza, W. (2007). Calcium homeostasis and acidocalcisomes in Toxoplasma gondii. In:The biology of Toxoplasma gondii. Eds: James Ajioka and Dominique Soldati. Horizon Scientific press. Chapter 26. 

2006

• Fang J, Marchesini N, Moreno SN. (2006) A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol. Biochem J.394:417.
• Harper JM, Huynh MH, Coppens I, Parussini F, Moreno SN, Carruters VB. A Cleavable Propeptide Influences Toxoplasma Infection by Facilitating the Trafficking and Secretion of the TgMIC2-M2AP Invasion Complex. (2006) Mol. Biol. Cell. 17(10):4551-63.

2005

• Luo, S., Ruiz, F.A., and Moreno, S.N.J. (2005) The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence. Mol. Microbiol. 55:1034-1045.
• Marshesini N, Vieira, M. Moreno, S.N.J., Docampo, R. A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte (2005). J. Biol. Chem.  280: 36841-7.
• Docampo, R., de Souza, W., Miranda, K., Rohloff, R., and Moreno, S.N.J. (2005) Acidocalcisomes –conserved from bacteria to man. Nat. Rev. Microbiol. 3:251-261.
• Okura M, Fang J, Salto ML, Singer RS, Docampo R, Moreno S.N.J. (2005) A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J. Biol. Chem. 280:16235-43.
• Ling, Y., Sahota, G., Odeh, S., Chan, J.M., Araujo, F., Moreno, S.N.J. and Oldfield, E. (2005) Bisphosphonate inhibitors of Toxoplasma gondii growth: in vitro, QSAR and in vivo investigations. J. Med. Chem. 48:3130-3140.